منابع مشابه
Clinical experience with 6-aminonicotinamide.
The toxicity of 6-Aminonicotinamide in 60 patients with advanced malignant disease has been described. The toxicity took two clinical forms: a "deficiency" state with char acteristics of a mixed B-complex vitamin deficiency, and a neurologic disturbance pre sumably due to a direct action on the central nervous system. Individual susceptibility was widely variable. 6-Aminonicotinamide exhibited ...
متن کامل6-Aminonicotinamide-resistant mutants of Salmonella typhimurium.
Resistance to the nicotinamide analog 6-aminonicotinamide has been used to identify the following three new classes of mutants in pyridine nucleotide metabolism. (i) pncX mutants have Tn10 insertion mutations near the pncA locus which reduce but do not eliminate the pncA product, nicotinamide deamidase. (ii) nadB (6-aminonicotinamide-resistant) mutants have dominant alleles of the nadB gene, wh...
متن کاملAugmentation of 6-Aminonicotinamide Antagonism of Tumor
The hormonal derivatives diethylstilbestrol, hexestrol, dienestrol, cortisone, estradiol-17a, estradiol-17/3, progesterone, and phloretin were compared with regard to their capacity to enhance carcinostasis in the presence of the niacin antagonist 6aminonicotinamide. Diethylstilbestrol and hexestrol were found to be more powerful than either estradiol-17/îor dienestrol. Phloretin, estradiol-17...
متن کاملThe effect of 6-aminonicotinamide on limb development.
The morphological effect of the nicotinamide analogue 6-aminonicotinamide on the development of the embryonic chick limb was studied, with special reference to muscle, cartilage, feather germ formation, and ossification. No evidence was found to support theories of control of differentiation by nicotinamide-like substances, although the effect of nicotinamide analogues has often been quoted as ...
متن کاملUltrastructural ocular lesions of 6-aminonicotinamide toxicosis in rabbits.
6-Aminonicotinamide, given by intraperitoneal injection to male and female Dutch belted rabbits, produced swelling and vacuolation of ciliary and iridal epithelium plus vacuolation of the retinal pigment epithelial and outer plexiform layers of the retina. By transmission electron microscopy, inner and outer ciliary epithelial cells and inner iridal epithelial cells contained numerous coalescin...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2012
ISSN: 1600-5368
DOI: 10.1107/s1600536812031224